St. Ann's College was established in 1981 by the Sisters Society of St. Ann. The Founder was Smt. Thatipatri Gnanamma; a visionary who dedicated her life to enlighten and educate poor young girls.[ St.Ann’s College started as a Junior College that was upgraded to a degree college in 1983 and progressed to offering Post Graduation programs since 1991 oriented towards the cause of need-based education, aiming at optimum growth.

The College is affiliated to Osmania University and the executive committee of the National Assessment and Accreditation Council (NAAC) on the recommendation of the duly appointed Peer Team declared St. Ann's College for women Accredited at the 'A' Level on 17 October 2006.

At present the College has a strength of over 2800 students and 100 lecturers. The College consists of three blocks which offers a variety of courses and options varying from Intermediate to PG in Arts, Social Sciences, Commerce and Business Management and Sciences.