The PRECISE-HBR score predicts major bleeding after percutaneous coronary intervention (PCI), enabling standardized risk stratification in clinical practice and trials. The PRECISE-HBR score was developed by augmenting the PRECISE-DAPT score with the Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria and has improved performance over the PRECISE-DAPT score, the ARC-HBR criteria, and many other risk scores.