Alpha-1 Antitrypsin Deficiency (AATD)

It is a free, quick and accessible consultation application, intended for healthcare personnel, that addresses the different aspects of Alpha-1 Antitrypsin (DAAT) deficiency, from clinical suspicion, diagnosis, treatment and genetic counseling. It also includes a calculator to help the healthcare professional establish the dosage of Alfa11-antitrypsin administration.

Prepared by SEPAR experts with the collaboration of members of the Catalan-Aragonese group of DAAT Experts and members of the Spanish Alpha-1 Antitrypsin Deficiency Network (REDAAT).

Bibliography used to create the calculator:
Prolastin 1000 mg technical sheet. Spanish Agency for Medicines and Health Products [Available at: https://cima.aemps.es/cima/dochtml/ft/68087/FichaTecnica_68087.html].
Respreeza 1000, 4000 and 5000 mg technical sheet. Spanish Agency for Medicines and Health Products. [Available at: https://cima.aemps.es/cima/dochtml/ft/1151006002/FT_1151006002.html].
Esquinas C, Miravitlles M. Are There Differences Between the Available Treatments for Emphysema Associated with Alpha-1 Antitrypsin Deficiency? Arch Bronconeumol (Engl Ed). 2018 Sep;54(9):451-452
Greulich T et. to the; RAPID Trial Group. Safety of biweekly α1-antitrypsin treatment in the RAPID programme. Eur Respir J. 2018 Nov 29;52(5):1800897. doi: 10.1183/13993003.00897-2018. PMID: 30237305; PMCID: PMC6557539.
I am D, de la Roza C, Lara B, et al. Alpha-1-antitrypsin deficiency: optimal therapeutic regimen based on population pharmacokinetics. Thorax 2006;61:1059-1064


The Alpha-1 Antitrypsin Deficiency APP is free and is exclusively available to members of SEPAR (Spanish Society of Pulmonology and Thoracic Surgery) with the usual passwords (login and password) commonly used on the website of the Scientific and Scientific Society. all its corporate, informational and scientific platforms.

This medicine application offers general and educational information on health topics, but is not a substitute for professional consultation. The information presented is of a general nature and should not be considered personalized medical advice. Users are urged to seek the guidance of a healthcare professional before making decisions related to their well-being. Although we strive to provide accurate information, its accuracy or timeliness is not guaranteed. The user is responsible for the use of the application, and no liability is assumed for resulting damages. In emergency cases, it is recommended to seek immediate medical attention.