Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass. These cancerous cells have the ability to invade other parts of the body.There are a number of types of pancreatic cancer.The most common, pancreatic adenocarcinoma, accounts for about 90% of cases,and the term "pancreatic cancer" is sometimes used to refer only to that type.These adenocarcinomas start within the part of the pancreas which makes digestive enzymes.Several other types of cancer, which collectively represent the majority of the non-adenocarcinomas, can also arise from these cells.One to two percent of cases of pancreatic cancer are neuroendocrine tumors, which arise from the hormone-producing cells of the pancreas.These are generally less aggressive than pancreatic adenocarcinoma.

Signs and symptoms of the most-common form of pancreatic cancer may include yellow skin, abdominal or back pain, unexplained weight loss, light-colored stools, dark urine, and loss of appetite.There are usually no symptoms in the disease's early stages, and symptoms that are specific enough to suggest pancreatic cancer typically do not develop until the disease has reached an advanced stage.By the time of diagnosis, pancreatic cancer has often spread to other parts of the body.

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