A smoothie can be made from blended raw fruit, vegetables with other ingredients such as water, ice, or sweeteners.

In addition to blended fruit/vegetables, smoothies may include other ingredients such as water, crushed ice, fruit juice, sweeteners ( honey, sugar, stevia, syrup), dairy products ( milk, yogurt, or cottage cheese, whey powder), plant milk, nuts, nut butter, seeds, tea, chocolate, herbal supplements, or nutritional supplements.

The healthfulness of a smoothie depends on its ingredients. Many smoothies include large servings of fruits and vegetables which are recommended in a healthful diet.