The PCI Global Summit 2025 is an interventional cardiology conference welcoming world-leading experts to Cairo, Egypt, on December 4-5. The summit's theme is "Real-Life Challenging Cases: Teaching & Decision," focusing on exploring complex procedures like CHIP, TAVI, CTO, and ACS. Through real-life cases, interactive simulators, and expert discussions, the event aims to advance global cardiovascular education by highlighting technical steps, complication management, and crucial decision-making in complex scenarios.