The direct oral anticoagulants User Guide was produced by health professionals (doctors, pharmacists (ne) s and nurses) working in the University Centers of the Quebec region. It is a practical reference book and easy to read for all professionals (general practitioners, specialists, pharmacists (ne) s and nurse (st) s) involved in monitoring patients for which direct oral anticoagulants (dabigatran ( Pradaxaᵐᵈ), rivaroxaban (Xareltoᵐᵈ), apixaban (Eliquisᵐᵈ) or edoxaban (Lixianaᵐᵈ)) was prescribed. The guide provided information on indications and criteria for reimbursement, dosages (including adjustment in renal failure), precautions and cons-indications, pharmacokinetics, interactions, management of peri and post-operative, the management of bleeding, as well as recommendations on the monitoring of patients. Useful calculators for calculating creatinine clearance and for risk scales CHADS₂, HAS-BLED CHA₂DS₂VASC and were incorporated to facilitate patient care.

However, users should consider that the guide was first created by and for professionals in the health of University Centers of the Quebec region with the peculiarities of their specialized areas. The use of the guide must be adapted depending on the environment and clinical judgment.

The application of the AODs User Guide is a realization of Effenti inc. (Www.effenti.ca)