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The Santa Fe Trail was a 19th-century route through central North America that connected Franklin, Missouri with Santa Fe, New Mexico. Pioneered in 1821 by William Becknell, who departed from the Boonslick region along the Missouri River, the trail served as a vital commercial highway until 1880, when the railroad arrived in Santa Fe. Santa Fe was near the end of the El Camino Real de Tierra Adentro, which carried trade from Mexico City.