He made his acting debut in the film industry with the critically acclaimed movie "Vicky Donor" in 2012, for which he won the Filmfare Award for Best Male Debut. Ayushmann is known for his choice of unconventional roles and his ability to portray complex characters with depth.

Some of his notable movies include "Dum Laga Ke Haisha," "Bareilly Ki Barfi," "Shubh Mangal Saavdhan," "Andhadhun," "Badhaai Ho," "Article 15," and "Dream Girl." Many of these films were both commercially successful and critically acclaimed, and Ayushmann's performances were widely appreciated.

Apart from acting, Ayushmann is also a talented singer and has sung songs for several of his films. He has released several singles as well. Ayushmann Khurrana is considered one of the most talented and versatile actors in the Indian film industry.