Ana Maria VS Zombies is about escaping from one place to another by defeating enemies in a short period of time. In this game, the player needs to escape from one place to another by killing zombies.

There are yellow keys needed to open the gates, and the player needs to pick them up and head towards the gate. Time is limited and the player has no life bar.

If the zombie attacks or touches the player, Ana Maria dies.

The gameplay is not that simple, controlling Ana Maria can be a bit difficult and she can shoot the zombies to destroy them.

Similarly, in another level, there are more zombies with high difficulty to get the key.