Pudhumaipithan was born in Thiruppadirippuliyur (Cuddalore) in a Saiva pillai family. His early education was obtained in places like Gingee, Kallakurichi and Tindivanam. He completed his Bachelor of Arts Degree from Tirunelveli Hindu college in 1931. In the same year he married Kamala and moved to Madras.
His career as a writer began in 1933 with an essay "Gulabjaan Kaadhal" (Love for Gulab jamun) published in the magazine Gandhi. His first short story "Aatrangarai Pillaiyaar" (Pillaiyaar on the river bank) was published in 1934 in "Manikodi" and from then on his short stories appeared regularly in it. His short stories appeared in a number of magazines like Kalaimakal, Jothi, Sudantira Chanku, Oozhiyan and Thamizh Mani and the annual issue of Dina Mani. He worked briefly as a sub editor at Oozhiyan and later at Dina Mani. In 1943, he left Dina Mani to join Dinasari. In 1940, his book "Pudhumaipithan Kadhaigal"(The stories of Pudhumaipithan), an anthology of his short stories was published. He slowly ventured into the world of Tamil cinema and worked as a scriptwriter in the films Avvaiyaar and KaamaValli. In 1945, he started "Parvatha Kumari Productions" and made an abortive attempt at producing a film called "Vasanthavalli". While working for the movie "Raja Mukthi", in Pune he contracted tuberculosis. He died on 5 May 1948 at Thiruvananthapuram.