Introductory Prayer on the Crucifix:
O Jesus, full of grace and charity, victim for sinners, so impelled by Your love of us that You willed to die on the cross, I humbly entreat you to glorify in heaven and earth, the servant of God, Padre Pio of Pietrelcina, who generously participated in your sufferings, who loved You so much and laboured so faithfully for the glory of Your heavenly Father and for the good of souls. With confidence, I beseech You to grant me, through his intercession, the grace of (present your request here ...) which I ardently desire.

On each set of three beads say one Our Father, one Hail Mary and one Glory Be.

Concluding Prayer of Padre Pio, prayed on the medal (optional):
Stay with me, Lord, for it is necessary to have You present so that I do not forget you. You know how easily I abandon you.
Stay with me, Lord, because I am weak and I need Your strength, that I may not fall so often.
Stay with me, Lord, for You are my life and without You I am without fervour.
Stay with me, Lord, for You are my light and without You I am in darkness.
Stay with me, Lord, to show me your will.
Stay with me, Lord, so that I hear Your voice and follow You.
Stay with me, Lord, for I desire to love You very much and always be in Your company.
Stay with me, Lord, if You wish me to be faithful to you.
Stay with me, Lord, as poor as my soul is, I want it to be a place of consolation for You, a nest of Love.
Stay with me, Jesus, for it is getting late and the day is coming to a close and life passes; death, judgment and eternity approach. It is necessary to renew my strength, so that I will not stop along the way and for that I need you. It is getting late and death approaches; I fear the darkness, the temptations, the dryness, the cross, the sorrows. O how I need You, my Jesus in this night of exile!
Stay with me tonight, Jesus; in life with all its dangers, I need You.
Let me recognise You as your disciples did at the breaking of the bread, so that the Eucharistic Communion be the Light which disperses the darkness, the force which sustains me, the unique joy of my heart.
Stay with me, Lord, because at the hour of my death, I want to remain united to You, if not by Communion, at least by grace and love.
Stay with me, Lord, for it is You alone I look for, Your love, Your grace, Your will, Your heart, Your Spirit, because I love You and ask no other reward but to love You more and more.
With a firm love, I will love You with all my heart while on earth and continue to love You perfectly during all eternity.
Amen.