Abruzzo (Abbrùzze, Abbrìzze or Abbrèzze in Neapolitan Abruzzese; Aquilano: Abbrùzzu) or Abruzzi is a region of Southern Italy with an area of 10,763 square km (4,156 sq mi) and a population of 1.2 million. It is divided into four provinces: L'Aquila, Teramo, Pescara, and Chieti. Its western border lies 80 km (50 mi) east of Rome. Abruzzo borders the region of Marche to the north, Lazio to the west and south-west, Molise to the south-east, and the Adriatic Sea to the east. Geographically, Abruzzo is divided into a mountainous area in the west, which includes the Gran Sasso d'Italia, and a coastal area in the east with beaches on the Adriatic Sea.

Abruzzo is considered a region of Southern Italy in terms of its culture, language, history and economy, although geographically it may also be considered central.The Italian Statistical Authority (ISTAT) also deems it to be part of Southern Italy, partly because of Abruzzo's historic association with the Kingdom of the Two Sicilies.

Abruzzo is known as "the greenest region in Europe" as almost half of its territory, the largest in Europe,is set aside as national parks and protected nature reserves. There are three national parks, one regional park, and 38 protected nature reserves. These ensure the survival of 75% of Europe's living species, including rare species such as the golden eagle, the Abruzzo (or Abruzzese) chamois, the Apennine wolf and the Marsican brown bear.[10] Abruzzo is also home to Calderone, Europe's southernmost glacier.

The visiting nineteenth-century Italian diplomat and journalist Primo Levi (1853–1917) said that the adjectives "forte e gentile" (strong and kind) best describe the beauty of the region and the character of its people. "Forte e gentile" has since become the motto of the region and its inhabitants.